Abstract ISG15. an interferon-stimulated ubiquitin-like protein. plays a multifaceted role in tumorigenesis and immune regulation. This study comprehensively evaluates ISG15 as a prognostic biomarker and predictor of immunotherapy response through pan-cancer bioinformatics analysis and experimental validation. https://herbsdailyes.shop/product-category/slippers-and-slipper-socks/