Neuropeptide- and hormone-containing secretory granules (SGs) are synthesized at the trans-Golgi network (TGN) as immature secretory granules (ISGs) and complete their maturation in the F-actin-rich cell cortex. This maturation process is characterized by acidification-dependent processing of cargo proteins. condensation of the SG matrix and removal of membrane and proteins not destin... https://www.roneverhart.com/Donitsirauta-MDI-Donut-900/